Safety of Subcutaneous Piperacillin/Tazobactam Administration Compared to Intravenous Administration: Propensity Score–Matched Cohort Study

Currently, the subcutaneous administration of antibiotics is considered to be an alternative route to intravenous administration because of its safety and effectiveness in treating bacterial infection,1 leading to its widespread use, especially for palliative purposes.2 Oral intolerance, poor venous access, refusal or contraindication of central venous access, and refusal or contraindication of intramuscular administration are common reasons for choosing subcutaneous administration of antibiotics.