Preventing Alzheimer's Disease: Why Not Targeting the Muscle First?

Alzheimer's disease (AD) is the commonest cause of dementia and in fact the most frequent neurologic disorder that accompanies the ageing process, currently affecting more than 30 million persons around the world.1 Although research is rapidly progressing, AD prevalence continues to rise worldwide, and currently available treatments produce minimal improvements, prompting the need for new strategies, including nonpharmacologic approaches. In this regard, a key lifestyle intervention, regular physical activity (PA), might play a major role in AD prevention,2 with the pandemic of physical inactivity being at odds with our biological makeup.