Plasma Klotho and Mortality Risk Among Nursing Home Residents: Results From the SENIOR Cohort

Several authors suggest that circulating klotho, a single-pass transmembrane protein, could be associated with longevity.1–4 This study aimed to test the relationship between the level of plasma Klotho and mortality among a specific population of nursing home residents. To address this objective, we measured plasma klotho levels in a longitudinal cohort of 662 nursing home residents, the SENIOR cohort.5 A sample of 443 subjects from the SENIOR cohort with archived blood samples available at the point of enrollment was included in the current study.