Deprescribing Glucose-Lowering Therapy in Older Adults with Diabetes: A Systematic Review of Recommendations

Overtreatment by glucose-lowering treatment (GLT) is frequent, and may induce harmful hypoglycemic events in older people with type 2 diabetes (T2D), significantly increasing morbidity and mortality.1 Avoiding overtreatment by GLT, either by prescribing appropriate GLT according to their individual risks-benefits balance or by deprescribing GLT, is therefore a key issue in the management of older patients, as recommended by various scientific societies these last years.2 Nevertheless, there is currently no consensus on the definition of GLT overtreatment in older people,3 which prevents a clear statement on which patients should undergo deprescribing of GLT.