Clostridioides difficile: New Insights on Management in the Older Patient

April 1, 2024
Caring for the Ages

Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated infective diarrhea in the United States. According to the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) clinical practice guidelines, antibiotics are the standard-of-care treatment for CDI (Clin Infect Dis 2018;66:e1–e48); however, 20% to 35% of patients who initially respond to antibiotics experience recurrent CDI, and up to 60% of these individuals experience additional recurrences (Clin Infect Dis 2012;55(Suppl 2):S154–61; Can J Hosp Pharm 2013;66(6):361–8).