Predictors of Inappropriate Dosing of Direct Oral Anticoagulants in Nonagenarian Patients With Atrial Fibrillation

Direct oral anticoagulants (DOACs) are presented as a good option for older patients owing to their safety profile. However, the dosing of these drugs can become challenging. This is due to the fluctuation of renal function in this population, together with the presence of comorbidities and the concomitant use of other drugs, among other reasons. Prior studies reported high rates of nonstandard dosing in older patients,1 increasing the risk of adverse events.2