Measure What Matters Most in Sarcopenia: Regional vs. Appendicular Muscle Mass?

Sarcopenia is an important public health problem as it relates to physical frailty, mobility limitation, and even premature death.1 Although the importance of age-related loss of muscle mass and function (ie, sarcopenia) has been known for decades, sarcopenia still does not have a universally agreed clinical definition and diagnostic criteria. Therefore, its reported prevalence ranges between 10% and 40% depending on the assessment techniques, diagnostic criteria, and characteristics of the populations.