Factors Associated With Response to Repeated Cerebrospinal Fluid Removal Procedures in Nonsurgical Candidates With Idiopathic Normal Pressure Hydrocephalus

Patients affected by idiopathic normal-pressure hydrocephalus (iNPH) are usually older and frail, and if left untreated, will inevitably undergo a significant decline in their functional status.1 In a previous work, we explored the safety and effectiveness of repeated cerebrospinal fluid (CSF) removal procedures (CSF tap) for the management of iNPH symptoms in patients ineligible for surgical intervention. Treated patients tended to remain functionally and cognitively stable over an up to 42-month follow-up period compared with those who, for different reasons, did not follow the protocol.