Antipsychotic Drugs, Fracture Risk, and Frailty in Older Patients

I read the recent article published in this journal and written by Gafoor et al1 with great interest. The authors conducted a prospective study to evaluate the effect of first- or second-generation antipsychotic drugs on fracture risk with special reference to levels of frailty in patients aged 80 years and older. Fracture incidence increased with frailty progression, and frail patients received more frequent antipsychotic drug treatment than nonfrail patients. Adjusted rate ratios (RRs) [95% confidence intervals (CIs)] of the first and second generation antipsychotic drug exposure on the risk of any fracture were 1.24 (1.07‒1.43) and 1.12 (1.01‒1.24), respectively.