Antihypertensive Drugs, Incident Dementia, and the Competing Risk of Death

In the article “Antihypertensive Medication Regimen Intensity and Incident Dementia in an Older Population” by Tan et al, the authors reported that in a prospective observational population-based cohort of 1208 older persons (mean age: 84.1 ± 5.6), use of a higher number of antihypertensive drug (AHD) classes was associated with a lower dementia risk during 6 years of follow-up.1 Cox regression was used to estimate hazard ratios (HRs), and competing risk of death was adjusted for using the subdistribution hazard method of Fine and Gray.