Rethinking Apathy and Gait: Clinical Implications for Dementia and Integrated Care

There is increasing recognition that a broader array of biological changes may contribute to the clinical expression of cognitive decline. As such, an emerging and often overlooked consideration in dementia is apathy, gait dysfunction, motoric-cognitive risk syndrome, and their interplay. Broadly, apathy, gait dysfunction, and motoric-cognitive risk may reflect changes across multiple physiological and neural systems acting as clinical markers bridging normal aging and overt dementia, thereby offering a framework to better understand and monitor dementia risk, management, and prognosis.